New data highlights the gaps in care for children with familial hypercholesterolemia

Children's Health

Children born with a common genetic condition, familial hypercholesterolemia (FH), are at increased risk for atherosclerotic cardiovascular disease (ASCVD) early in life. Despite long-standing national guidelines, cholesterol screening — for children at age 2 for those with a family history of heart disease and between the ages of nine to 11 for all children — is not being implemented .

New data from the FH Foundation’s CASCADE FH Registry highlights the gaps in care for children with FH, published online today in The Journal of Pediatrics. Among nearly 500 children and adolescents with FH, diagnosis occurred on average at nine years of age, seven years later than cholesterol screening guidelines.

It is critical to identify children with familial hypercholesterolemia in order to prevent cardiovascular disease through early treatment intervention. The U.S. guidelines are clear but there is a low level of implementing these guidelines that put nearly 300,000 children at risk.”

Sarah de Ferranti, MD, MPH, chief, division of ambulatory cardiology, Boston Children’s Hospital, and CASCADE FH Registry principal investigator

FH causes a high level of low-density lipoprotein cholesterol (LDL-C) from birth, that left untreated can cause early ASCVD including heart attacks and strokes. Treatment can begin as early as eight years old and is recommended to start no later than 10 years of age. One recent long-term study published in the New England Journal of Medicine demonstrated that initiating statins in childhood and continuing statins into adulthood led to a reduction of cardiovascular events as compared to their parents with the same genetic disorder.

Youth in the registry began lipid-lowering therapy on average at 11 years of age, with statins the most frequently reported medication (n=271; 56.2%). In addition, 23.5% of children eligible for treatment were not receiving therapy at enrollment. Only 39% of the youth achieved recommended LDL-C reduction according to U.S. and international guidelines (LDL-C <130 mg/DL or a 50 percent reduction from the highest pretreatment LDL-C levels).

“Consequences are devastating when familial hypercholesterolemia is missed, with one in ten heart attacks under 45 caused by FH. Yet evidence shows that we can dramatically change this paradigm with early identification and treatment,” said Katherine Wilemon, founder and CEO of the FH Foundation. “We will continue to advocate for increased research and awareness of FH as a common cause of premature heart disease in all members of affected families.”

Journal reference:

de Ferranti, S.D., et al. (2020) Children with Heterozygous Familial Hypercholesterolemia in the United States: Data from the Cascade Screening for Awareness and Detection-FH Registry. Journal of Pediatrics. doi.org/10.1016/j.jpeds.2020.09.042.

Articles You May Like

Study sheds new light on impact of COVID-19 in pediatric population
Study highlights need for policies to mitigate racial, ethnic disparities in adults
FDA approves first ever medication for rare genetic diseases that cause premature aging, death
Baby Bottle Tooth Decay: Causes, Signs, And Prevention
Decades of research into racial, ethnic health disparities fail to resolve disproportionate health outcomes

Leave a Reply

Your email address will not be published. Required fields are marked *